Behavioral characterization of P311 knockout mice

Correction: Behavioral and Electrophysiological Characterization of Dyt1 Heterozygous Knockout Mice

The following information is missing from the Funding section: This study was supported by the Bachmann-Strauss Dystonia and Parkinson Foundation, Inc. The complete, correct funding information is as follows: This work was supported by Tyler’s Hope for a Dystonia Cure, Inc., Dystonia Medical Research Foundation, Bachmann-Strauss Dystonia and Parkinson Foundation, Inc., National Institutes of He...

Behavioral and Electrophysiological Characterization of Dyt1 Heterozygous Knockout Mice

DYT1 dystonia is an inherited movement disorder caused by mutations in DYT1 (TOR1A), which codes for torsinA. Most of the patients have a trinucleotide deletion (ΔGAG) corresponding to a glutamic acid in the C-terminal region (torsinA(ΔE)). Dyt1 ΔGAG heterozygous knock-in (KI) mice, which mimic ΔGAG mutation in the endogenous gene, exhibit motor deficits and deceased frequency of spontaneous ex...

Characterization of inducible SYK knockout mice

Behavioural characterization of prodynorphin knockout mice

Dynorphin, with a high selectivity for kappa opioid receptors, is a member of the opioid peptide family. Application of opioid agonists and antagonists revealed crucial effects of the opioid system in numerous physiological functions. However, data obtained are often contradictive, reflecting the complex situation of the cross-activation of 3 receptors through a peptide derived from 3 different...

Behavioral Characterization of β-Arrestin 1 Knockout Mice in Anxiety-Like and Alcohol Behaviors

β-Arrestin 1 and 2 are highly expressed proteins involved in the desensitization of G protein-coupled receptor signaling which also regulate a variety of intracellular signaling pathways. Gene knockout (KO) studies suggest that the two isoforms are not homologous in their effects on baseline and drug-induced behavior; yet, the role of β-arrestin 1 in the central nervous system has been less inv...